Pijnlijke ontsteking en zwelling na verwonding, bijvoorbeeld na verstuiking. Wanneer mag u Cataflam niet gebruiken? Deze stoffen kunt u vinden onder rubriek 6. Wanneer moet u extra voorzichtig zijn met Cataflam? Neem contact op met uw arts of apotheker voordat u Cataflam inneemt. Voordat u diclofenac gebruikt, vertel het uw arts: De kans op bijwerkingen kan verkleind worden door de laagste werkzame dosering te gebruiken gedurende de kortst mogelijke periode.
Cataflam is aangewezen voor behandelingen van korte duur. Indien Cataflam, uitzonderlijk, wordt voorgeschreven voor een behandeling van langere duur, moet uw bloed regelmatig worden geanalyseerd. Geneesmiddelen zoals Cataflam kunnen in verband worden gebracht met klein verhoogd risico op een hartaanval 'hartinfarct' of beroerte.
Neem niet meer in dan de voorgeschreven dosis en gebruik het geneesmiddel niet langer dan de voorgeschreven behandeling. Het risico neemt toe naarmate de ingenomen dosis hoger is en het geneesmiddel langer gebruikt worden. Gebruikt u nog andere geneesmiddelen? Gebruikt u naast Cataflam nog andere geneesmiddelen, of heeft u dat kort geleden gedaan of bestaat de mogelijkheid dat u in de nabije toekomst andere geneesmiddelen gaat gebruiken?
Vertel dat dan uw arts of apotheker. Waarop moet u letten met eten en drinken? Het is aanbevolen Cataflam in te nemen voor de maaltijd of met een lege maag. Zwangerschap, borstvoeding en vruchtbaarheid Bent u zwanger, denkt u zwanger te zijn, wilt u zwanger worden of geeft u borstvoeding? Dosage Information in more detail What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.
Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while taking Cataflam? It may increase your risk of stomach bleeding.
Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to diclofenac. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
Cataflam side effects Get emergency medical help if you have signs of an allergic reaction to Cataflam: Get emergency medical help if you have signs of a heart attack or stroke: Stop using Cataflam and call your doctor at once if you have: Co-morbid conditions such as coagulation disorders, concomitant use of warfarin and other anticoagulants, antiplatelet agents e.
Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids and the patient should be observed closely for any evidence of adverse effects, including adrenal insufficiency and exacerbation of symptoms of arthritis.
The pharmacological activity of Cataflam in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions. Information for Patients Advise the patient to read the FDA-approved patient labeling Medication Guide that accompanies each prescription dispensed.
Inform patients, families, or their caregivers of the following information before initiating therapy with Cataflam and periodically during the course of ongoing therapy. Cardiovascular Thrombotic Events Advise patients to be alert for the symptoms of cardiovascular thrombotic events, including chest pain, shortness of breath, weakness, or slurring of speech, and to report any of these symptoms to their healthcare provider immediately see WARNINGS; Cardiovascular Thrombotic Events.
Gastrointestinal Bleeding, Ulceration, and Perforation Advise patients to report symptoms of ulcerations and bleeding, including epigastric pain, dyspepsia, melena, and hematemesis to their health care provider. Heart Failure and Edema Advise patients to be alert for the symptoms of congestive heart failure including shortness of breath, unexplained weight gain, or edema and to contact their healthcare provider if such symptoms occur see WARNINGS; Heart Failure and Edema.
Anaphylactic Reactions Inform patients of the signs of an anaphylactic reaction eg, difficulty breathing, swelling of the face or throat. Masking of Inflammation and Fever The pharmacological activity of Cataflam in reducing fever and inflammation, and possibly fever, may diminish the utility of these diagnostic signs in detecting infections.
Drug Interactions See Table 2 for clinically significant drug interactions with diclofenac. Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.
Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Monitor patients with concomitant use of Cataflam with anticoagulants e. Cataflam is not a substitute for low dose aspirin for cardiovascular protection. In patients who are elderly, volume-depleted including those on diuretic therapy , or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.
These effects are usually reversible. During concomitant use of Cataflam and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter.
Clinical studies, as well as postmarketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics e. During concomitant use of Cataflam with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects see WARNINGS; Renal Toxicity and Hyperkalemia.
The concomitant use of diclofenac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.
During concomitant use of Cataflam and digoxin, monitor serum digoxin levels. NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. During concomitant use of Cataflam and lithium, monitor patients for signs of lithium toxicity. During concomitant use of Cataflam and methotrexate, monitor patients for methotrexate toxicity. During concomitant use of Cataflam and cyclosporine, monitor patients for signs of worsening renal function.
Concomitant use of Cataflam and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity see the pemetrexed prescribing information.
NSAIDs with short elimination half-lives e. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives e. Co-administration of diclofenac with CYP2C9 inhibitors e. A 2-year carcinogenicity study conducted in mice employing diclofenac sodium at doses up to 0.
Mutagenesis Diclofenac sodium did not show mutagenic activity in in vitro point mutation assays in mammalian mouse lymphoma and microbial yeast, Ames test systems and was nonmutagenic in several mammalian in vitro and in vivo tests, including dominant lethal and male germinal epithelial chromosomal studies in mice, and nucleus anomaly and chromosomal aberration studies in Chinese hamsters.
Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including Cataflam, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulation.
Consider withdrawal of NSAIDs, including Cataflam, in women who have difficulties conceiving or who are undergoing investigation of infertility. Pregnancy Risk Summary Use of NSAIDs, including Cataflam, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. There are no adequate and well-controlled studies of Cataflam in pregnant women. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive.
In the general U. In animal reproduction studies, no evidence of teratogenicity was observed in mice, rats, or rabbits given diclofenac during the period of organogenesis at doses up to approximately 0. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization.
In animal studies, administration of prostaglandin synthesis inhibitors such as diclofenac, resulted in increased pre- and post-implantation loss.
These maternally toxic doses were associated with dystocia, prolonged gestation, reduced fetal weights and growth, and reduced fetal survival.
Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly. Tell your doctor if 5mg are pregnant or plan cataflam become pregnant. Dispense in tight container USP. Neem de vergeten tablet in van zodra u eraan denkt. Hoe bewaart u Cataflam? Vertel dat dan uw arts of apotheker. 5mg moet u letten met eten en drinken? Deze stoffen kunt u vinden onder rubriek 6, cataflam 46 5mg. Both diclofenac and its oxidative metabolites undergo glucuronidation or sulfation followed by biliary excretion. For treatment of pain or primary dysmenorrhea the recommended dosage is 50 mg three times a cataflam. Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding, cataflam 46 5mg.
NSAIDs have produced elevations in plasma 5mg levels and reductions in renal lithium clearance. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen. Waarop cataflam u cataflam met eten en drinken? Voordat u diclofenac gebruikt, cataflam 46 5mg, vertel het uw arts: In animal studies, administration of prostaglandin synthesis inhibitors such as diclofenac, resulted in increased pre- and post-implantation loss. Postmarketing surveillance has reported cases of severe hepatic reactions, cataflam 46 5mg, including 5mg necrosis, cataflam 46 5mg, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Drug Interactions See Table 2 for clinically significant drug interactions with diclofenac. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Use the lowest dose that is effective in treating your condition. Avoid the use of Cataflam in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal function. 5mg is not approved for use by anyone younger than 18 years old. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives cataflam.
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